Which two agents are categorized as irritants and prompt consideration of a central access port?

• A. Docetaxel and Carboplatin
• B. Paclitaxel and Vincristine
• C. Daunorubicin and Mechlorethamine
• D. Epirubicin and Vinblastine

Answer: (A)

Irritants are drugs that irritate the vein and can cause phlebitis, but they don’t typically cause tissue necrosis if a spill occurs. Because of this, they’re often given through a peripheral line, but for longer courses or when the veins are fragile, using a central venous access port can protect the veins and ensure reliable delivery. Docetaxel and carboplatin are considered irritants, so this combination best fits the idea of prompting consideration of a central port. The other pairs include drugs that are known vesicants, which have a higher risk of severe tissue injury if extravasation occurs, and those typically demand central access as well, but the question targets the irritant category.