Which treatment regimen is used for colorectal cancer described in the material?

• A. FOLFOX6
• B. XELOX (CAPOX)
• C. FOLFIRINOX
• D. FOLFIRI

Answer: (A)

This regimen combines an oxaliplatin backbone with a fluoropyrimidine and leucovorin to treat colorectal cancer. Oxaliplatin damages DNA in cancer cells, while leucovorin boosts the activity of 5-FU, a fluoropyrimidine that inhibits DNA synthesis. The combination is typically given in two-week cycles with 5-FU delivered as a continuous infusion, optimizing exposure of cancer cells to the drug.

Other regimens differ in drug choices or administration: using capecitabine (an oral 5-FU prodrug) with oxaliplatin is a related option but not the same IV continuous-infusion approach; using irinotecan instead of oxaliplatin defines a different regimen; and regimens like FOLFIRINOX are aimed at pancreatic cancer and include additional agents.