Which practice is specifically used to prevent central line–associated bloodstream infections (CLABSI)?

• A. Catheter Care Bundle for Prevention of Central Line Associated Infection
• B. Daily Antibiotic Prophylaxis
• C. Prophylactic Antifungal Alone
• D. Frequent IV Tubing Changes

Answer: (A)

Preventing CLABSI relies on a coordinated, evidence-based approach to both inserting and maintaining central lines. A Catheter Care Bundle brings together multiple proven practices into one consistent protocol: strict hand hygiene, full sterile barrier precautions during insertion, chlorhexidine for skin antisepsis, careful selection of insertion site when possible, maintaining a closed catheter system, proper hub and tubing care, and daily assessment with removal of lines that are no longer needed. Because infection risk comes from how the line is handled and maintained, implementing these steps together reduces opportunities for pathogens to enter the bloodstream much more effectively than any single action.

Daily antibiotic prophylaxis and prophylactic antifungal therapy are not recommended for CLABSI prevention, as they don’t reliably lower infection rates and can lead to resistance and other harms. Simply changing IV tubing more frequently also does not prevent infections and can increase line manipulation, potentially raising risk.