Which PPE item is essential when handling hazardous drugs to minimize exposure?

• A. Two pairs of chemotherapy gloves
• B. A simple cotton gown
• C. A standard surgical mask
• D. Open-toed shoes

Answer: (A)

Protecting the skin from hazardous drugs is the most important line of defense, because skin contact is a main exposure route. Wearing two pairs of chemotherapy gloves gives the strongest barrier: the outer glove shields against spills and splashes, while the inner glove remains intact if the outer one is damaged, providing added protection during handling and disposal. A simple cotton gown isn’t impermeable and can allow drug penetration, so it won’t reliably protect skin. A standard surgical mask doesn’t guard against inhalation of drug aerosols, and open-toed shoes leave feet vulnerable to spills. So, the best answer is wearing two pairs of chemotherapy gloves to minimize exposure.