Which of the following is a DNA-binding antineoplastic agent?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Prepare for the ONS ONCC Chemotherapy Exam. Enhance your skills with multiple choice questions and detailed explanations. Ensure you're ready for certification renewal!

Multiple Choice

Which of the following is a DNA-binding antineoplastic agent?

Explanation:
DNA-binding antineoplastic agents disrupt cancer cell replication by directly interacting with DNA. Doxorubicin intercalates into the DNA helix, inserting between base pairs, and also inhibits topoisomerase II, which prevents proper DNA unwinding and replication. Paclitaxel, Vincristine, and Vinorelbine work by targeting microtubules—Paclitaxel stabilizes microtubules, while Vincristine and Vinorelbine inhibit microtubule formation—so they do not bind DNA. Therefore, doxorubicin is the drug that directly binds DNA, making it the correct choice.

DNA-binding antineoplastic agents disrupt cancer cell replication by directly interacting with DNA. Doxorubicin intercalates into the DNA helix, inserting between base pairs, and also inhibits topoisomerase II, which prevents proper DNA unwinding and replication. Paclitaxel, Vincristine, and Vinorelbine work by targeting microtubules—Paclitaxel stabilizes microtubules, while Vincristine and Vinorelbine inhibit microtubule formation—so they do not bind DNA. Therefore, doxorubicin is the drug that directly binds DNA, making it the correct choice.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy