Which non-drug-related factor is a risk for mucositis, independent of chemotherapy or radiation agents?

• A. Dehydration
• B. Use of bisphosphonates
• C. Vitamin C supplementation
• D. Exercise-induced fatigue

Answer: (A)

Dehydration is a factor that can worsen mucosal vulnerability on its own. When the mouth is dehydrated, saliva production drops and the mucosa becomes dry, irritated, and less protected. Saliva normally lubricates, cleanses, and helps maintain the health of the oral lining and aids in healing after minor injury. With reduced salivary flow, even everyday trauma or irritation can lead to mucosal breakdown and ulcers, increasing the risk of mucositis independent of any chemotherapy or radiation exposure.

The other options involve drugs or conditions that aren’t established non-drug-related risk factors for mucositis in the absence of cancer treatments, so they don’t fit the prompt as well.