Which drug category has no known antidote for extravasation?

• A. Ice Pack
• B. Warm Compress
• C. Hyaluronidase
• D. Taxanes

Answer: (D)

Not all extravasation injuries have an antidote, so treatment depends on the drug class. Some chemotherapies have targeted antidotes that can limit tissue damage after leakage. For example, an antidote is used for anthracyclines to reduce local injury, and hyaluronidase can be injected around the extravasation site to help disperse certain agents like vinca alkaloids and lessen necrosis. However, there is no proven antidote for extravasation of taxanes, such as paclitaxel or docetaxel. Because no antidote reverses or mitigates tissue injury for taxanes, this category is the one with no known antidote. In practice, management focuses on prompt stopping of the infusion, aspiration of residual drug, local measures and supportive care, with escalation to surgical assessment if necrosis develops. Ice or heat are local measures to influence spread, and hyaluronidase serves as an antidote for some drugs but not for taxanes.