What is the recommended dosing method for Hyaluronidase in plant alkaloid extravasation?

• A. 1 mL total divided into five injections of 0.2 mL
• B. 0.5 mL divided into ten injections
• C. 2 mL divided into two injections
• D. 1 mL in a single injection

Answer: (A)

Hyaluronidase helps the extravasated alkaloid spread through tissue by breaking down hyaluronic acid in the extracellular matrix, reducing local tissue pressure and limiting damage. For plant alkaloid extravasation, the best approach is to administer a total of 1 mL of hyaluronidase, typically 150 units/mL, given as five subcutaneous injections of 0.2 mL each around the infiltrated area. This pattern ensures even diffusion around the site, maximizing the enzyme’s effect and lowering the risk of focal tissue injury. Smaller total doses or injections concentrated in fewer sites don’t achieve as broad a local distribution, and a single injection won’t distribute the enzyme evenly across the affected area.