In Totect dosing for anthracycline extravasation, the dose is based on which parameter?

• A. Body Surface Area
• B. Weight
• C. Age
• D. Kidney Function

Answer: (A)

Dosing Totect for anthracycline extravasation is based on body surface area. The regimen uses doses expressed as mg per square meter (mg/m2), such as an initial dose of 1000 mg/m2 followed by 500 mg/m2 at 24 and 48 hours. Using body surface area helps scale the dose to the patient’s size, giving a proportional amount of the protective agent to tissue exposure risk across both children and adults.

Weight is not the basis for this regimen, because two patients with the same weight can have different body compositions and surface areas, leading to different tissue exposure. Age isn’t used as a dosing parameter here, since BSA already accounts for size differences across ages. Kidney function isn’t part of the standard calculation for this extravasation protocol, although overall monitoring is important; the dosing is specifically tied to body surface area to standardize protection against tissue damage.