In the FOLFOX6 regimen, what is the duration of the continuous infusion for 5-FU?

• A. 12 hours
• B. 24 hours
• C. 72 hours
• D. 46 hours

Answer: (D)

The important idea is that 5-FU works best when the drug stays in the body at effective levels for an extended period, so part of the regimen is given as a continuous infusion after an initial dose. In the FOLFOX6 schedule, after the 5-FU bolus, the continuous infusion runs for 46 hours. This prolonged exposure helps maximize tumor cell kill while keeping toxicity manageable, with the infusion often delivered via a pump that the patient can carry if needed. Shorter durations like 12 or 24 hours don’t provide the same sustained exposure, and a much longer infusion such as 72 hours isn’t standard due to increased toxicity and practicality.