In the administration of the FOLFOX6 regimen, which component is given as a bolus before the infusion?

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Prepare for the ONS ONCC Chemotherapy Exam. Enhance your skills with multiple choice questions and detailed explanations. Ensure you're ready for certification renewal!

Multiple Choice

In the administration of the FOLFOX6 regimen, which component is given as a bolus before the infusion?

Explanation:
In FOLFOX6 the 5-fluorouracil dose is given as a bolus before the continuous infusion. This bolus creates a rapid peak in Drug level to kick-start the cytotoxic effect, and then the same drug is delivered as a prolonged infusion to maintain exposure. Oxaliplatin is delivered as an infusion, not a bolus, and leucovorin is used to enhance 5-FU activity but is not the bolus administered before the infusion. So the component given as a bolus before the infusion is 5-FU.

In FOLFOX6 the 5-fluorouracil dose is given as a bolus before the continuous infusion. This bolus creates a rapid peak in Drug level to kick-start the cytotoxic effect, and then the same drug is delivered as a prolonged infusion to maintain exposure. Oxaliplatin is delivered as an infusion, not a bolus, and leucovorin is used to enhance 5-FU activity but is not the bolus administered before the infusion. So the component given as a bolus before the infusion is 5-FU.

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