How should a nurse respond to a suspected infusion-related reaction to a monoclonal antibody?

• A. Stop the infusion, assess airway and hemodynamics, treat per protocol, notify the physician, and decide about restarting at a slower rate if symptoms resolve.
• B. Continue the infusion at same rate.
• C. Discontinue chemotherapy permanently.
• D. Administer more infusion.

Answer: (A)

When a suspected infusion-related reaction occurs with a monoclonal antibody, the priority is to keep the patient safe by stopping the infusion and quickly assessing essential functions. Immediately halt the infusion to prevent further exposure, then focus on airway, breathing, and circulation. Check for airway patency, provide oxygen if needed, monitor vitals, and treat with the established protocol for infusion reactions (which may include fluids, antihistamines, corticosteroids, vasopressors, or other emergency measures as directed). After stabilizing the patient, notify the physician right away so they can guide next steps, including whether it’s appropriate to restart the infusion at a slower rate with enhanced monitoring and possible premedication. If symptoms resolve and the physician approves, the infusion can be resumed cautiously; if not, a change in therapy or permanent discontinuation may be considered, but this decision rests on clinical assessment and policy. Do not continue at the same rate, and do not administer more infusion during the reaction.