Besides capecitabine, which class may be associated with hand-foot syndrome?

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Prepare for the ONS ONCC Chemotherapy Exam. Enhance your skills with multiple choice questions and detailed explanations. Ensure you're ready for certification renewal!

Multiple Choice

Besides capecitabine, which class may be associated with hand-foot syndrome?

Explanation:
Hand-foot syndrome occurs when the drug reaches the skin of the palms and soles, causing redness, swelling, pain, and sometimes peeling. Capecitabine and 5-FU are the classic culprits, but other chemotherapy classes can also be associated with this toxicity. Among the options, taxanes such as docetaxel have a recognized association with hand-foot syndrome, especially at higher doses or with longer treatment courses. The other classes listed—vinca alkaloids, anthracyclines, and platinum agents—are more often linked to other toxicities like neuropathy, myelosuppression, or mucositis, and are not as commonly associated with hand-foot syndrome.

Hand-foot syndrome occurs when the drug reaches the skin of the palms and soles, causing redness, swelling, pain, and sometimes peeling. Capecitabine and 5-FU are the classic culprits, but other chemotherapy classes can also be associated with this toxicity. Among the options, taxanes such as docetaxel have a recognized association with hand-foot syndrome, especially at higher doses or with longer treatment courses. The other classes listed—vinca alkaloids, anthracyclines, and platinum agents—are more often linked to other toxicities like neuropathy, myelosuppression, or mucositis, and are not as commonly associated with hand-foot syndrome.

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